Monoclonal Antibody-Defined Specific C Epitope of Brucella O-Polysaccharide Revisited.
نویسندگان
چکیده
The C epitope of Brucella O-polysaccharide (O-PS) has so far lacked definitive structural identity. Revised structures for this antigen revealed a unique capping perosamine tetrasaccharide consisting of a sequence of 1,2:1,3:1,2 interresidue linkages. Here, using synthetic oligosaccharide glycoconjugates, the α-1,3 linkage of the O-PS is shown to be an integral structural requirement of this epitope. Although A-dominant strains possess only one or two copies of the capping tetrasaccharide, this creates a unique pentasaccharide antigenic determinant with the linkage sequence 1,2:1,3:1,2:1,2 that is always present in major pathogenic Brucella species.
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عنوان ژورنال:
- Clinical and vaccine immunology : CVI
دوره 22 8 شماره
صفحات -
تاریخ انتشار 2015